Biological markers in amyotrophic lateral sclerosis: help or hindrance?
نویسندگان
چکیده
منابع مشابه
Biological Spectrum of Amyotrophic Lateral Sclerosis Prions.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD) are two neurodegenerative diseases with distinct clinical features but common genetic causes and neuropathological signatures. Ten years after the RNA-binding protein TDP-43 was discovered as the main protein in the cytoplasmic inclusions that characterize ALS and FTLD, their pathogenic mechanisms have never seemed mor...
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Accepted for publication 14 March 1996. Systemic sclerosis (SSc) is a connective tissue disease characterised by an increased secretion of normal extracellular matrix proteins in mesenchymal tissue, and by widespread morphofunctional capillary abnormalities.' 2 Most of the clinical features of SSc are clearly related to vascular lesions; moreover, a diffuse microangiopathy is a prominent featur...
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The Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in the adulthood, and it is characterized by rapid and progressive compromise of the upper and lower motor neurons. The majority of the cases of ALS are classified as sporadic and, until now, a specific cause for these cases still is unknown. To present the different hypotheses on the etiology of ALS. It was...
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OBJECTIVE Mutations in the progranulin (PGRN) gene were recently described as the cause of ubiquitin positive frontotemporal dementia (FTD). Clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and FTD prompted us to screen PGRN in patients with ALS and ALS-FTD. METHODS The PGRN gene was sequenced in 272 cases of sporadic ALS, 40 cases of familial ALS and in 49 patien...
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The main aim of our study was monitoring of indices of anti-oxidant activity in SALS patients. 28 patients (13 males, 15 females; mean age 58.5±12, 3 years; mean duration 25.9±5, 5 months) were monitored during 6 months. Every month the patients were examined neurologically, ALS functional rating scale, the pulmonary dysfunction by measurement of FVC, evaluated functional disability. The indice...
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ژورنال
عنوان ژورنال: Journal of Neurology
سال: 1999
ISSN: 0340-5354
DOI: 10.1007/pl00007752